A hand holds out a white capsule of fast-acting migraine remedy in a convenient capsule for ingestion, a friend's hand holds a glass of water.

Migraine medication from the migraine specialists.

At Hedfirst, we develop unique migraine compounds for unique migraine experiences

Medical advisor: founder of the New York Headache Center
Licensed providers and New York magazine’s Best Doctors in New York
Certified pharmacy
Clinically proven, innovative compounds

Naratriptan 2.5mg + Duloxetine 15mg

NeurEase™ daily

migraine preventative.

A specialized compound that pairs migraine relief (Naratriptan 2.5mg) with nerve pain management (Duloxetine 15mg) in one daily capsule. Designed for migraine sufferers who experience significant nerve-related symptoms, this unique formulation helps address both the vascular and neuropathic components of migraine pain.

NeurEase™ purple pack - daily migraine prevention with sumatriptan and duloxetine for nerve and vascular pain relief.
DAILY PREVENTATIVE
A man scrutinizes the packaging of Hedfirst migraine medication.White round tablets with a dividing line lying on a light colored surface.

Need help?Talk to us.

We know it's not always easy to choose the right medication. Hedfirst's Customer Care team is here to help.
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Certified Medical Providers
Telehealth nurse counseling a patient about Hedfirst migraine treatment.

What our migraine patients are saying.

"Hedfirst's compound medication approach has simplified my migraine treatment into one solution that actually works."
A woman smiling in a black jacket.
Rachel L.
"The ability to message my provider whenever I have questions or need adjustments has been a game-changer for managing my migraines."
Happy elderly man in glasses and striped t-shirt.
Ethan B.
"Within two months of starting with Hedfirst, my migraine frequency dropped from 12 days per month to just 3 - I finally have my life back."
A woman wearing glasses smiles for the camera.
Emma R.

Your path to fewer migraines.

60-70%
Less migraine pain
Over 60-70% of patients who received migraine-specific treatment reported a significant reduction in headache intensity, improving their daily quality of life.
20-50%
Fewer migraine days
Clinical trials show that over 20-50% of patients using preventive treatments experienced fewer monthly migraine attacks, allowing them to regain control of their schedules.
85%
Satisfied with treatment
85% of patients who switched to an optimized migraine management plan found their treatment more effective compared to previous medications.
Empowering you to thrive mentally and emotionally.
Personalized migraine treatment customization screen in the Hedfirst app.

Not sure which medication you need? Answer a few questions and we'll make a recommendation.

"The future of migraine treatment lies in intelligent combination therapies. At Hedfirst, we've developed compound formulations that combine proven medications for comprehensive relief."

Dr. Alexander Mauskop, Chief Medical Advisor at Hedfirst, expert in migraine treatment.
Dr. Alexander Mauskop
Hedfirst Chief Medical Advisor
Director, New York Headache Center
Professor of Clinical Neurology, SUNY Downstate Medical Center

100% online.
100% convenient.

Telemedicine nurse smiling sweetly in overalls.
Providers in most states.
A man's hand holds a migraine treatment capsule.
Clinically-proven ingredients.
The screen of the Hedfirst Migraine Relief app, an interface for managing migraine treatment.
Responsive customer care.
SumaRelief™ gray pack is a dual-action migraine remedy that combines sumatriptan and naproxen in one convenient capsule.
Fast, discreet shipping.

We get migraines - our medication advisor has been conducting research in the field of headaches for over 30 years.

A woman sitting on a couch taking Hedfirst migraine medication.
Older man with a beard taking a ZolmEase™ capsule for migraine and nausea relief, with product details overlaid.
100% online
Licensed providers
Unique compounds
FDA ingredients
No insurance required
Free shipping
No hidden fees
No office visits
Physician reviewed
Unique formulations